Onglyza
Generic Name: saxagliptin (SAX a GLIP tin)
Brand Names: Onglyza
What is Onglyza?
Onglyza (saxagliptin) is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating.
Onglyza is for people with type 2 diabetes (non-insulin-dependent) diabetes. Onglyza is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes.
Onglyza may also be used for purposes not listed in this medication guide.
Important information about Onglyza
Do not use Onglyza if you are allergic to saxagliptin or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
Before you take Onglyza, tell your doctor if you have kidney disease or if you are on dialysis.
You may take this medicine with or without food. Follow your doctor's instructions.
Onglyza is only part of a complete program of treatment that also includes diet, exercise, weight control, and possibly other medications. It is important to use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Before taking Onglyza
Do not use Onglyza if you are allergic to saxagliptin, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
To make sure you can safely take Onglyza, tell your doctor if you have kidney disease or if you are on dialysis.
FDA pregnancy category B. Onglyza is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether saxagliptin passes into breast milk or if it could harm a nursing baby. Do not use Onglyza without telling your doctor if you are breast-feeding a baby. Onglyza should not be given to a child younger than 18 years old without a doctor's advice.
See also: Onglyza pregnancy and breastfeeding warnings (in more detail)
How should I take Onglyza?
Take Onglyza exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results.
You may take Onglyza with or without food. Follow your doctor's instructions.
Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, drink alcohol, or skip meals. These things can affect your glucose levels and your dose needs may also change.
Your doctor may want you to stop taking Onglyza for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency.
Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.
Onglyza is only part of a complete program of treatment that also includes diet, exercise, weight control, and possibly other medications. It is important to use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Store Onglyza at room temperature away from moisture and heat.
See also: Onglyza dosage (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember (be sure to take the medicine with food if your doctor has instructed you to). Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).
What should I avoid while taking Onglyza?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Onglyza side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Onglyza: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
pain or burning when you urinate;
swelling in your hands, ankles, or feet; or
easy bruising or bleeding.
Less serious Onglyza side effects may include:
runny or stuffy nose, sore throat, cough;
headache; or
stomach pain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Onglyza side effects (in more detail)
What other drugs will affect Onglyza?
Tell your doctor about all other medications you use, especially:
conivaptan (Vaprisol);
diclofenac (Arthrotec, Cataflam, Voltaren, Flector Patch, Solareze);
imatinib (Gleevec);
isoniazid (for treating tuberculosis);
an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek);
an antidepressant such as nefazodone;
antifungal medication such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);
heart or blood pressure medication such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others;
HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir); or
insulin or an oral diabetes medication such as glipizide (Glucotrol, Metaglip), glimepiride (Amaryl, Avandaryl, Duetact), glyburide (DiaBeta, Micronase, Glucovance), and others.
This list is not complete and other drugs may interact with Onglyza. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More Onglyza resources
Onglyza Side Effects (in More Detail)
Onglyza Dosage
Onglyza Use in Pregnancy & Breastfeeding
Onglyza Drug Interactions
Onglyza Support Group
5 Reviews for Onglyza - Add your own review/rating
Onglyza Prescribing Information (FDA)
Onglyza Advanced Consumer (Micromedex) - Includes Dosage Information
Onglyza MedFacts Consumer Leaflet (Wolters Kluwer)
Saxagliptin Professional Patient Advice (Wolters Kluwer)
Compare Onglyza with other medications
Diabetes, Type 2
Where can I get more information?
Your pharmacist can provide more information about Onglyza.
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