Estradiol

Estradiol

Generic Name: estradiol oral (ess tra DYE ole)

Brand Names: Estrace, Femtrace, Gynodiol

What is estradiol?

Estradiol is a form of estrogen, a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Estradiol is used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. Estradiol is sometimes used as part of cancer treatment in women and men.

Estradiol may also be used for other purposes not listed in this medication guide.

Important information about estradiol

Estradiol can harm an unborn baby or cause birth defects. Do not use estradiol if you are pregnant. You should not take estradiol if you have abnormal vaginal bleeding, liver disease, breast or uterine cancer, hormone-dependent cancer, a recent history of heart attack or stroke, if you are pregnant, if you have ever had a blood clot (especially in your lung or your lower body), or if you are allergic to any medicines or food dyes. Taking hormones can increase your risk of blood clots, stroke, or heart attack, especially if you have diabetes, high blood pressure, high cholesterol or triglycerides, if you smoke, or if you are overweight.

Long-term estradiol treatment may increase your risk of breast cancer, ovarian cancer, or uterine cancer. Talk with your doctor about your individual risks before using estradiol long-term. Your doctor should check your progress every 3 to 6 months to determine whether you should continue this treatment.

Taking progestin while using estradiol may lower your risk of uterine cancer. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol.

Estradiol should not be used to prevent heart disease, stroke, or dementia, because this medication may actually increase your risk of developing these conditions.

Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while using estradiol.

Before using estradiol

You should not take estradiol if you are allergic to it, or if you have:

liver disease;

abnormal vaginal bleeding that a doctor has not checked;

any type of breast, uterine, or hormone-dependent cancer;

a recent history of heart attack or stroke;

if you are pregnant;

if you have ever had a blood clot (especially in your lung or your lower body); or

if you are allergic to any medicines or food dyes.

Taking hormones can increase your risk of blood clots, stroke, or heart attack, especially if you have risk factors such as diabetes, high blood pressure, high cholesterol or triglycerides, smoking, or being overweight.

To make sure you can safely take estradiol, tell your doctor if you have any of these other conditions:

heart disease;

kidney disease;

family history of blood clots;

a history of jaundice caused by pregnancy or taking hormones;

endometriosis;

lupus;

porphyria;

gallbladder disease;

underactive thyroid;

asthma;

epilepsy or other seizure disorder;

migraines;

low levels of calcium in your blood; or

if you have had your uterus removed (hysterectomy).

FDA pregnancy category X. Estradiol can harm an unborn baby or cause birth defects. Do not use estradiol if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Estradiol can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. You should not breast-feed while you are taking estradiol. Estradiol should not be used to prevent heart disease, stroke, or dementia, because this medication may actually increase your risk of developing these conditions.

See also: Estradiol pregnancy and breastfeeding warnings (in more detail)

How should I use estradiol?

Take estradiol exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.

Long-term estradiol treatment may increase your risk of breast cancer, ovarian cancer, or uterine cancer. Talk with your doctor about your individual risks before using estradiol long-term.

Taking progestin while using estradiol may lower your risk of uterine cancer. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol.

Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while using estradiol. Your doctor should check your progress every 3 to 6 months to determine whether you should continue this treatment.

If you need medical tests or surgery, or if you will be on bed rest, you may need to stop using this medication for a short time. Any doctor or surgeon who treats you should know that you are taking estradiol.

Store estradiol at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause nausea, vomiting, or vaginal bleeding.

What should I avoid while using estradiol?

Do not smoke while using estradiol. Smoking can increase your risk of blood clots, stroke, or heart attack caused by estradiol.

Estradiol side effects

Get emergency medical help if you have any of these signs of an allergic reaction to estradiol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using estradiol and call your doctor at once if you have a serious side effect such as:

unusual vaginal bleeding (especially if you are past menopause);

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

sudden numbness or weakness, especially on one side of the body;

sudden severe headache, confusion, problems with vision, speech, or balance;

stabbing chest pain, sudden cough, wheezing, rapid breathing, fast heart rate;

pain, swelling, warmth, or redness in one or both legs;

nausea, vomiting, loss of appetite, increased thirst, muscle weakness, confusion, and feeling tired or restless;

a lump in your breast;

feeling like you might pass out;

pain, swelling, or tenderness in your stomach; or

jaundice (yellowing of the skin or eyes).

Less serious estradiol side effects may include:

mild nausea, vomiting, bloating, stomach cramps;

breast pain, tenderness, or swelling;

freckles or darkening of facial skin;

loss of scalp hair;

vaginal itching or discharge; or

changes in your menstrual periods, break-through bleeding.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect estradiol?

Tell your doctor about all other medicines you use, especially:

a blood thinner such as warfarin (Coumadin);

cimetidine (Tagamet);

carbamazepine (Carbatrol, Tegretol);

phenobarbital (Luminal, Solfoton);

phenytoin (Dilantin);

rifampin (Rifadin, Rifater, Rifamate, Rimactane); or

ritonavir (Norvir);

St. John's wort;

an antibiotic such as clarithromycin (Biaxin) or erythromycin (E-Mycin, E.E.S., Erythrocin, Ery-Tab); or

antifungal medication such as ketoconazole (Extina, Ketozole, Nizoral, Xolegal).

This list is not complete and other drugs may interact with estradiol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Estradiol resources

Estradiol Dosage

Estradiol Use in Pregnancy & Breastfeeding

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Estradiol Drug Interactions

Estradiol Support Group

55 Reviews for Estradiol - Add your own review/rating

Estradiol Monograph (AHFS DI)

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Elestrin Gel MedFacts Consumer Leaflet (Wolters Kluwer)

Elestrin Prescribing Information (FDA)

Estrace MedFacts Consumer Leaflet (Wolters Kluwer)

Estrace Prescribing Information (FDA)

Estrace Advanced Consumer (Micromedex) - Includes Dosage Information

Estraderm Patch MedFacts Consumer Leaflet (Wolters Kluwer)

Estraderm Prescribing Information (FDA)

Estradiol Patch Prescribing Information (FDA)

Estrasorb Prescribing Information (FDA)

Estrasorb Emulsion MedFacts Consumer Leaflet (Wolters Kluwer)

EstroGel Prescribing Information (FDA)

EstroGel Gel MedFacts Consumer Leaflet (Wolters Kluwer)

Evamist Prescribing Information (FDA)

Evamist Spray MedFacts Consumer Leaflet (Wolters Kluwer)

Femring Ring MedFacts Consumer Leaflet (Wolters Kluwer)

Femring Prescribing Information (FDA)

Femtrace MedFacts Consumer Leaflet (Wolters Kluwer)

Femtrace Prescribing Information (FDA)

Femtrace Advanced Consumer (Micromedex) - Includes Dosage Information

Menostar Prescribing Information (FDA)

Menostar Weekly Patch MedFacts Consumer Leaflet (Wolters Kluwer)

Vivelle Prescribing Information (FDA)

Vivelle-Dot Prescribing Information (FDA)

Compare Estradiol with other medications

Atrophic Urethritis

Atrophic Vaginitis

Breast Cancer, Palliative

Hypoestrogenism

Oophorectomy

Osteoporosis

Postmenopausal Symptoms

Primary Ovarian Failure

Prostate Cancer

Where can I get more information?

Your pharmacist can provide more information about estradiol.